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Nonparametric Analysis of Thermal Proteome Profiles Reveals Novel Drug-binding Proteins

Detecting the targets of drugs and other molecules in intact cellular contexts is a major objective in drug discovery and in biology more broadly. Thermal proteome profiling (TPP) pursues this aim at proteome-wide scale by inferring target engagement from its effects on temperature-dependent protein...

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Publicado en:Mol Cell Proteomics
Autores principales: Childs, Dorothee, Bach, Karsten, Franken, Holger, Anders, Simon, Kurzawa, Nils, Bantscheff, Marcus, Savitski, Mikhail M., Huber, Wolfgang
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6885700/
https://ncbi.nlm.nih.gov/pubmed/31582558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.TIR119.001481
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