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Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP

Adenosine triphosphate (ATP) plays fundamental roles in cellular biochemistry and was recently discovered to function as a biological hydrotrope. Here, we use mass spectrometry to interrogate ATP-mediated regulation of protein thermal stability and protein solubility on a proteome-wide scale. Therma...

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Foilsithe in:Nat Commun
Main Authors: Sridharan, Sindhuja, Kurzawa, Nils, Werner, Thilo, Günthner, Ina, Helm, Dominic, Huber, Wolfgang, Bantscheff, Marcus, Savitski, Mikhail M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411743/
https://ncbi.nlm.nih.gov/pubmed/30858367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09107-y
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