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Nonparametric Analysis of Thermal Proteome Profiles Reveals Novel Drug-binding Proteins
Detecting the targets of drugs and other molecules in intact cellular contexts is a major objective in drug discovery and in biology more broadly. Thermal proteome profiling (TPP) pursues this aim at proteome-wide scale by inferring target engagement from its effects on temperature-dependent protein...
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| Vydáno v: | Mol Cell Proteomics |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The American Society for Biochemistry and Molecular Biology
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6885700/ https://ncbi.nlm.nih.gov/pubmed/31582558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.TIR119.001481 |
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