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Thermal proteome profiling for interrogating protein interactions

Thermal proteome profiling (TPP) is based on the principle that, when subjected to heat, proteins denature and become insoluble. Proteins can change their thermal stability upon interactions with small molecules (such as drugs or metabolites), nucleic acids or other proteins, or upon post‐translatio...

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Bibliografiske detaljer
Udgivet i:Mol Syst Biol
Main Authors: Mateus, André, Kurzawa, Nils, Becher, Isabelle, Sridharan, Sindhuja, Helm, Dominic, Stein, Frank, Typas, Athanasios, Savitski, Mikhail M
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7057112/
https://ncbi.nlm.nih.gov/pubmed/32133759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20199232
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