Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death

As pathogenic Parkin mutations result in the defective clearance of damaged mitochondria, Parkin-dependent mitophagy is thought to be protective against the dopaminergic neurodegeneration observed in Parkinson’s disease. Recent studies, however, have demonstrated that Parkin can promote cell death i...

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Vydáno v:Cell Death Dis
Hlavní autoři: De Snoo, Mitchell L., Friesen, Erik L., Zhang, Yu Tong, Earnshaw, Rebecca, Dorval, Geneviève, Kapadia, Minesh, O’Hara, Darren M., Agapova, Victoria, Chau, Hien, Pellerito, Ornella, Tang, Matthew Y., Wang, Xinzhu, Schmitt-Ulms, Gerold, Durcan, Thomas M., Fon, Edward A., Kalia, Lorraine V., Kalia, Suneil K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6885512/
https://ncbi.nlm.nih.gov/pubmed/31787745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-2132-x
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