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The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications
Two Parkinson's disease (PD)-associated proteins, the mitochondrial kinase PINK1 and the E3-ubiquitin (Ub) ligase PARKIN, are central to mitochondrial quality control. In this pathway, PINK1 accumulates on defective mitochondria, eliciting the translocation of PARKIN from the cytosol to mediate...
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| Publicado no: | Genes Dev |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4441056/ https://ncbi.nlm.nih.gov/pubmed/25995186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.262758.115 |
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