Short Mitochondrial ARF Triggers Parkin/PINK1-dependent Mitophagy

Parkinson disease (PD) is a complex neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra. Multiple genes have been associated with PD, including Parkin and PINK1. Recent studies have established that the Parkin and PINK1 proteins function in a common mi...

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Bibliographic Details
Main Authors: Grenier, Karl, Kontogiannea, Maria, Fon, Edward A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207970/
https://ncbi.nlm.nih.gov/pubmed/25217637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.607150
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