LAM-003, a new drug for treatment of tyrosine kinase inhibitor–resistant FLT3-ITD–positive AML

Acute myeloid leukemias (AML) harboring a constitutively active internal tandem duplication (ITD) mutation in the FMS-like kinase tyrosine kinase (FLT3) receptor are associated with poor patient prognosis. Despite initial clinical responses to FLT3 kinase inhibitors, patients eventually relapse. Mec...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Beeharry, Neil, Landrette, Sean, Gayle, Sophia, Hernandez, Marylens, Grotzke, Jeff E., Young, Peter R., Beckett, Paul, Zhang, Xuan, Carter, Bing Z., Andreeff, Michael, Halene, Stephanie, Xu, Tian, Rothberg, Jonathan, Lichenstein, Henri
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880894/
https://ncbi.nlm.nih.gov/pubmed/31751472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019001068
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