SETBP1 overexpression acts in the place of class-defining mutations to drive FLT3-ITD–mutant AML

Advances in cancer genomics have revealed genomic classes of acute myeloid leukemia (AML) characterized by class-defining mutations, such as chimeric fusion genes or in genes such as NPM1, MLL, and CEBPA. These class-defining mutations frequently synergize with internal tandem duplications in FLT3 (...

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Udgivet i:Blood Adv
Main Authors: Pacharne, Suruchi, Dovey, Oliver M., Cooper, Jonathan L., Gu, Muxin, Friedrich, Mathias J., Rajan, Sandeep S., Barenboim, Maxim, Collord, Grace, Vijayabaskar, M. S., Ponstingl, Hannes, De Braekeleer, Etienne, Bautista, Ruben, Mazan, Milena, Rad, Roland, Tzelepis, Konstantinos, Wright, Penny, Gozdecka, Malgorzata, Vassiliou, George S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2021
Fag:
Myeloid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8114559/
https://ncbi.nlm.nih.gov/pubmed/33956058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003443
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