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Using Chemical Inhibitors to Probe AAA protein conformational dynamics and cellular functions

The AAA proteins are a family of enzymes that play key roles in diverse dynamic cellular processes, ranging from proteostasis to directional intracellular transport. Dysregulation of AAA proteins has been linked to several diseases, including cancer, suggesting a possible therapeutic role for inhibi...

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Dades bibliogràfiques
Publicat a:Curr Opin Chem Biol
Autors principals: Steinman, Jonathan B, Kapoor, Tarun M
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880239/
https://ncbi.nlm.nih.gov/pubmed/30913482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2019.02.019
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