Flexibility in Nucleic Acid Binding Is Central to APOBEC3H Antiviral Activity

APOBEC3 proteins APOBEC3F (A3F), APOBEC3G (A3G), and APOBEC3H (A3H) are host restriction factors that inhibit HIV-1 through DNA cytidine deaminase-dependent and -independent mechanisms and have either one (A3H) or two (A3F and A3G) zinc-binding domains. A3H antiviral activity encompasses multiple mo...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Bohn, Jennifer A., DaSilva, Justin, Kharytonchyk, Siarhei, Mercedes, Maria, Vosters, Jennifer, Telesnitsky, Alice, Hatziioannou, Theodora, Smith, Janet L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
Soggetti:
Cellular Response to Infection
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880157/
https://ncbi.nlm.nih.gov/pubmed/31578294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01275-19
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