APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA

The APOBEC3 family of cytidine deaminases cause lethal hypermutation of retroviruses via deamination of newly reverse-transcribed viral DNA. Their ability to bind RNA is essential for virion infiltration and antiviral activity, yet the mechanisms of viral RNA recognition are unknown. By screening na...

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Udgivet i:Nat Commun
Main Authors: Bohn, Jennifer A., Thummar, Keyur, York, Ashley, Raymond, Alice, Brown, W. Clay, Bieniasz, Paul D., Hatziioannou, Theodora, Smith, Janet L.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647330/
https://ncbi.nlm.nih.gov/pubmed/29044109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01309-6
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