Inhibition of the ubiquitous calpains protects complex I activity and enables improved mitophagy in the heart following ischemia-reperfusion

Activation of calpain 1 (CPN1) and calpain 2 (CPN2) contributes to cardiac injury during ischemia (ISC) and reperfusion (REP). Complex I activity is decreased in heart mitochondria following ISC-REP. CPN1 and CPN2 are ubiquitous calpains that exist in both cytosol (cs)-CPN1 and 2 and mitochondria (m...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Am J Physiol Cell Physiol
Main Authors: Chen, Qun, Thompson, Jeremy, Hu, Ying, Dean, Joseph, Lesnefsky, Edward J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879877/
https://ncbi.nlm.nih.gov/pubmed/31411917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00190.2019
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados