Inhibition of the ubiquitous calpains protects complex I activity and enables improved mitophagy in the heart following ischemia-reperfusion

Activation of calpain 1 (CPN1) and calpain 2 (CPN2) contributes to cardiac injury during ischemia (ISC) and reperfusion (REP). Complex I activity is decreased in heart mitochondria following ISC-REP. CPN1 and CPN2 are ubiquitous calpains that exist in both cytosol (cs)-CPN1 and 2 and mitochondria (m...

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Pubblicato in:Am J Physiol Cell Physiol
Autori principali: Chen, Qun, Thompson, Jeremy, Hu, Ying, Dean, Joseph, Lesnefsky, Edward J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879877/
https://ncbi.nlm.nih.gov/pubmed/31411917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00190.2019
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