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Ribosome depurination by ricin leads to inhibition of endoplasmic reticulum stress–induced HAC1 mRNA splicing on the ribosome

Ricin undergoes retrograde transport to the endoplasmic reticulum (ER), and ricin toxin A chain (RTA) enters the cytosol from the ER. Previous reports indicated that RTA inhibits activation of the unfolded protein response (UPR) in yeast and in mammalian cells. Both precursor (preRTA) and mature for...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Pierce, Michael, Vengsarkar, Diana, McLaughlin, John E., Kahn, Jennifer N., Tumer, Nilgun E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879324/
https://ncbi.nlm.nih.gov/pubmed/31624149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009128
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