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Ricin Inhibits Activation of the Unfolded Protein Response by Preventing Splicing of the HAC1 mRNA
Ricin A chain (RTA) inhibits protein synthesis by removing a specific adenine from the highly conserved α-sarcin/ricin loop in the large rRNA. Expression of RTA with its own signal sequence in yeast resulted in its translocation into the endoplasmic reticulum (ER) and subsequent glycosylation. Becau...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3024914/ https://ncbi.nlm.nih.gov/pubmed/18180297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707981200 |
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