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Ricin Inhibits Activation of the Unfolded Protein Response by Preventing Splicing of the HAC1 mRNA

Ricin A chain (RTA) inhibits protein synthesis by removing a specific adenine from the highly conserved α-sarcin/ricin loop in the large rRNA. Expression of RTA with its own signal sequence in yeast resulted in its translocation into the endoplasmic reticulum (ER) and subsequent glycosylation. Becau...

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Hlavní autoři: Parikh, Bijal A., Tortora, Andrew, Li, Xiao-Ping, Tumer, Nilgun E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024914/
https://ncbi.nlm.nih.gov/pubmed/18180297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707981200
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