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Ricin Inhibits Activation of the Unfolded Protein Response by Preventing Splicing of the HAC1 mRNA

Ricin A chain (RTA) inhibits protein synthesis by removing a specific adenine from the highly conserved α-sarcin/ricin loop in the large rRNA. Expression of RTA with its own signal sequence in yeast resulted in its translocation into the endoplasmic reticulum (ER) and subsequent glycosylation. Becau...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Parikh, Bijal A., Tortora, Andrew, Li, Xiao-Ping, Tumer, Nilgun E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2008
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024914/
https://ncbi.nlm.nih.gov/pubmed/18180297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707981200
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