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Ribosome Depurination Is Not Sufficient for Ricin-Mediated Cell Death in Saccharomyces cerevisiae

The plant toxin ricin is one of the most potent and lethal substances known. Ricin inhibits protein synthesis by removing a specific adenine from the highly conserved α-sarcin/ricin loop in the large rRNA. Very little is known about how ricin interacts with ribosomes and the molecular mechanism by w...

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Bibliografische gegevens
Hoofdauteurs: Li, Xiao-Ping, Baricevic, Marianne, Saidasan, Hemalatha, Tumer, Nilgun E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2007
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1828414/
https://ncbi.nlm.nih.gov/pubmed/17101666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01295-06
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