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Arginine Residues on the Opposite Side of the Active Site Stimulate the Catalysis of Ribosome Depurination by Ricin A Chain by Interacting with the P-protein Stalk

Ricin inhibits protein synthesis by depurinating the α-sarcin/ricin loop (SRL). Ricin holotoxin does not inhibit translation unless the disulfide bond between the A (RTA) and B (RTB) subunits is reduced. Ricin holotoxin did not bind ribosomes or depurinate them but could depurinate free RNA. When RT...

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書誌詳細
主要な著者: Li, Xiao-Ping, Kahn, Peter C., Kahn, Jennifer Nielsen, Grela, Przemysław, Tumer, Nilgun E.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798493/
https://ncbi.nlm.nih.gov/pubmed/24003229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.510966
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