Safety and Pharmacokinetics of a Four Monoclonal Antibody Combination against Botulinum C and D Neurotoxins

Botulism is caused by botulinum neurotoxin (BoNT), the most poisonous substance known. BoNTs are also classified as tier 1 biothreat agents due to their high potency and lethality. The existence of seven BoNT serotypes (A to G), which differ by 35% to 68% in amino acid sequences, necessitates the de...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Snow, Doris M., Riling, Kathryn, Kimbler, Angie, Espinoza, Yero, Wong, David, Pham, Khanh, Martinez, Zachary, Kraus, Carl N., Conrad, Fraser, Garcia-Rodriguez, Consuelo, Cobb, Ronald R., Marks, James D., Tomic, Milan T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Clinical Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879217/
https://ncbi.nlm.nih.gov/pubmed/31591130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01270-19
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