A three monoclonal antibody combination potently neutralizes multiple botulinum neurotoxin serotype F subtypes

Human botulism is primarily caused by botulinum neurotoxin (BoNT) serotypes A, B and E, with around 1% caused by serotype F (BoNT/F). BoNT/F comprises at least seven different subtypes with the amino acid sequence difference between subtypes as high as 36%. The sequence differences present a signifi...

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發表在:PLoS One
Main Authors: Fan, Yongfeng, Garcia-Rodriguez, Consuelo, Lou, Jianlong, Wen, Weihua, Conrad, Fraser, Zhai, Wenwu, Smith, Theresa J., Smith, Leonard A., Marks, James D.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2017
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360321/
https://ncbi.nlm.nih.gov/pubmed/28323873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174187
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