Monoclonal Antibodies that Inhibit the Proteolytic Activity of Botulinum Neurotoxin Serotype/B

Existing antibodies (Abs) used to treat botulism cannot enter the cytosol of neurons and bind to botulinum neurotoxin (BoNT) at its site of action, and thus cannot reverse paralysis. However, Abs targeting the proteolytic domain of the toxin could inhibit the proteolytic activity of the toxin intrac...

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Publicado en:Toxins (Basel)
Autores principales: Fan, Yongfeng, Dong, Jianbo, Lou, Jianlong, Wen, Weihua, Conrad, Fraser, Geren, Isin N., Garcia-Rodriguez, Consuelo, Smith, Theresa J., Smith, Leonard A., Ho, Mengfei, Pires-Alves, Melissa, Wilson, Brenda A., Marks, James D.
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591640/
https://ncbi.nlm.nih.gov/pubmed/26343720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins7093405
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