A Single Tri-Epitopic Antibody Virtually Recapitulates the Potency of a Combination of Three Monoclonal Antibodies in Neutralization of Botulinum Neurotoxin Serotype A

The standard of treatment for botulism, equine antitoxin, is a foreign protein with associated safety issues and a short serum half-life which excludes its use as a prophylactic antitoxin and makes it a less-than-optimal therapeutic. Due to these limitations, a recombinant monoclonal antibody (mAb)...

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Detalhes bibliográficos
Publicado no:Toxins (Basel)
Main Authors: Lou, Jianlong, Wen, Weihua, Conrad, Fraser, Meng, Qi, Dong, Jianbo, Sun, Zhengda, Garcia-Rodriguez, Consuelo, Farr-Jones, Shauna, Cheng, Luisa W., Henderson, Thomas D., Brown, Jennifer L., Smith, Theresa J., Smith, Leonard A., Cormier, Anthony, Marks, James D.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5848185/
https://ncbi.nlm.nih.gov/pubmed/29462889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins10020084
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