Monoclonal Antibodies that Inhibit the Proteolytic Activity of Botulinum Neurotoxin Serotype/B

Existing antibodies (Abs) used to treat botulism cannot enter the cytosol of neurons and bind to botulinum neurotoxin (BoNT) at its site of action, and thus cannot reverse paralysis. However, Abs targeting the proteolytic domain of the toxin could inhibit the proteolytic activity of the toxin intrac...

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Gepubliceerd in:Toxins (Basel)
Hoofdauteurs: Fan, Yongfeng, Dong, Jianbo, Lou, Jianlong, Wen, Weihua, Conrad, Fraser, Geren, Isin N., Garcia-Rodriguez, Consuelo, Smith, Theresa J., Smith, Leonard A., Ho, Mengfei, Pires-Alves, Melissa, Wilson, Brenda A., Marks, James D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591640/
https://ncbi.nlm.nih.gov/pubmed/26343720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins7093405
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