Monoclonal Antibodies that Inhibit the Proteolytic Activity of Botulinum Neurotoxin Serotype/B

Existing antibodies (Abs) used to treat botulism cannot enter the cytosol of neurons and bind to botulinum neurotoxin (BoNT) at its site of action, and thus cannot reverse paralysis. However, Abs targeting the proteolytic domain of the toxin could inhibit the proteolytic activity of the toxin intrac...

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Bibliografiske detaljer
Udgivet i:Toxins (Basel)
Main Authors: Fan, Yongfeng, Dong, Jianbo, Lou, Jianlong, Wen, Weihua, Conrad, Fraser, Geren, Isin N., Garcia-Rodriguez, Consuelo, Smith, Theresa J., Smith, Leonard A., Ho, Mengfei, Pires-Alves, Melissa, Wilson, Brenda A., Marks, James D.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591640/
https://ncbi.nlm.nih.gov/pubmed/26343720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins7093405
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