Monoclonal Antibody Combinations Prevent Serotype A and Serotype B Inhalational Botulism in a Guinea Pig Model

Botulinum neurotoxins (BoNT) are some of the most toxic proteins known, with a human LD(50) of ~1 ng/kg. Equine antitoxin has a half-life in circulation of less than 1 day and is limited to a treatment rather than a prevention indication. The development of monoclonal antibodies (mAbs) may represent...

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Detalhes bibliográficos
Publicado no:Toxins (Basel)
Main Authors: Tomic, Milan T., Espinoza, Yero, Martinez, Zachary, Pham, Khanh, Cobb, Ronald R., Snow, Doris M., Earnhart, Christopher G., Pals, Traci, Syar, Emily S., Niemuth, Nancy, Kobs, Dean J., Farr-Jones, Shauna, Marks, James D.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520708/
https://ncbi.nlm.nih.gov/pubmed/30959899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins11040208
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