mTORC1 feedback to AKT modulates lysosomal biogenesis through MiT/TFE regulation

The microphthalmia family of transcription factors (MiT/TFEs) controls lysosomal biogenesis and is negatively regulated by the nutrient sensor mTORC1. However, the mechanisms by which cells with constitutive mTORC1 signaling maintain lysosomal catabolism remain to be elucidated. Using the murine epi...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Asrani, Kaushal, Murali, Sanjana, Lam, Brandon, Na, Chan-Hyun, Phatak, Pornima, Sood, Akshay, Kaur, Harsimar, Khan, Zoya, Noë, Michaël, Anchoori, Ravi K., Talbot, C. Conover, Smith, Barbara, Skaro, Michael, Lotan, Tamara L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877313/
https://ncbi.nlm.nih.gov/pubmed/31527310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128287
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