mTORC1 loss impairs epidermal adhesion via TGF-β/Rho kinase activation

Despite its central position in oncogenic intracellular signaling networks, the role of mTORC1 in epithelial development has not been studied extensively in vivo. Here, we have used the epidermis as a model system to elucidate the cellular effects and signaling feedback sequelae of mTORC1 loss of fu...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Asrani, Kaushal, Sood, Akshay, Torres, Alba, Georgess, Dan, Phatak, Pornima, Kaur, Harsimar, Dubin, Amber, Talbot, C. Conover, Elhelu, Loubna, Ewald, Andrew J., Xiao, Bo, Worley, Paul, Lotan, Tamara L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663351/
https://ncbi.nlm.nih.gov/pubmed/28945203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92893
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