mTORC1 loss impairs epidermal adhesion via TGF-β/Rho kinase activation

Despite its central position in oncogenic intracellular signaling networks, the role of mTORC1 in epithelial development has not been studied extensively in vivo. Here, we have used the epidermis as a model system to elucidate the cellular effects and signaling feedback sequelae of mTORC1 loss of fu...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Asrani, Kaushal, Sood, Akshay, Torres, Alba, Georgess, Dan, Phatak, Pornima, Kaur, Harsimar, Dubin, Amber, Talbot, C. Conover, Elhelu, Loubna, Ewald, Andrew J., Xiao, Bo, Worley, Paul, Lotan, Tamara L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663351/
https://ncbi.nlm.nih.gov/pubmed/28945203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92893
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