mTORC1 loss impairs epidermal adhesion via TGF-β/Rho kinase activation

Despite its central position in oncogenic intracellular signaling networks, the role of mTORC1 in epithelial development has not been studied extensively in vivo. Here, we have used the epidermis as a model system to elucidate the cellular effects and signaling feedback sequelae of mTORC1 loss of fu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Clin Invest
Hauptverfasser: Asrani, Kaushal, Sood, Akshay, Torres, Alba, Georgess, Dan, Phatak, Pornima, Kaur, Harsimar, Dubin, Amber, Talbot, C. Conover, Elhelu, Loubna, Ewald, Andrew J., Xiao, Bo, Worley, Paul, Lotan, Tamara L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663351/
https://ncbi.nlm.nih.gov/pubmed/28945203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92893
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge