mTORC1 feedback to AKT modulates lysosomal biogenesis through MiT/TFE regulation

The microphthalmia family of transcription factors (MiT/TFEs) controls lysosomal biogenesis and is negatively regulated by the nutrient sensor mTORC1. However, the mechanisms by which cells with constitutive mTORC1 signaling maintain lysosomal catabolism remain to be elucidated. Using the murine epi...

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Bibliografiska uppgifter
I publikationen:J Clin Invest
Huvudupphovsmän: Asrani, Kaushal, Murali, Sanjana, Lam, Brandon, Na, Chan-Hyun, Phatak, Pornima, Sood, Akshay, Kaur, Harsimar, Khan, Zoya, Noë, Michaël, Anchoori, Ravi K., Talbot, C. Conover, Smith, Barbara, Skaro, Michael, Lotan, Tamara L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2019
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877313/
https://ncbi.nlm.nih.gov/pubmed/31527310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128287
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