Changing the Apoptosis Pathway through Evolutionary Protein Design

One obstacle in de novo protein design is the vast sequence space that needs to be searched through to obtain functional proteins. We developed a new method using structural profiles created from evolutionarily related proteins to constrain the simulation search process, with functions specified by...

詳細記述

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書誌詳細
出版年:J Mol Biol
主要な著者: Shultis, David, Mitra, Pralay, Huang, Xiaoqiang, Johnson, Jarrett, Khattak, Naureen Aslam, Gray, Felicia, Piper, Clint, Czajka, Jeff, Hansen, Logan, Wan, Bingbing, Chinnaswamy, Krishnapriya, Liu, Liu, Wang, Mi, Pan, Jingxi, Stuckey, Jeanne, Cierpicki, Tomasz, Borchers, Christoph H., Wang, Shaomeng, Lei, Ming, Zhang, Yang
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876990/
https://ncbi.nlm.nih.gov/pubmed/30625288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2018.12.016
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