Changing the Apoptosis Pathway through Evolutionary Protein Design

One obstacle in de novo protein design is the vast sequence space that needs to be searched through to obtain functional proteins. We developed a new method using structural profiles created from evolutionarily related proteins to constrain the simulation search process, with functions specified by...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Shultis, David, Mitra, Pralay, Huang, Xiaoqiang, Johnson, Jarrett, Khattak, Naureen Aslam, Gray, Felicia, Piper, Clint, Czajka, Jeff, Hansen, Logan, Wan, Bingbing, Chinnaswamy, Krishnapriya, Liu, Liu, Wang, Mi, Pan, Jingxi, Stuckey, Jeanne, Cierpicki, Tomasz, Borchers, Christoph H., Wang, Shaomeng, Lei, Ming, Zhang, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876990/
https://ncbi.nlm.nih.gov/pubmed/30625288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2018.12.016
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