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EvoDesign: de novo protein design based on structural and evolutionary profiles

Protein design aims to identify new protein sequences of desirable structure and biological function. Most current de novo protein design methods rely on physics-based force fields to search for low free-energy states following Anfinsen’s thermodynamic hypothesis. A major obstacle of such approaches...

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Dettagli Bibliografici
Autori principali: Mitra, Pralay, Shultis, David, Zhang, Yang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3692067/
https://ncbi.nlm.nih.gov/pubmed/23671331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt384
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