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EvoDesign: de novo protein design based on structural and evolutionary profiles

Protein design aims to identify new protein sequences of desirable structure and biological function. Most current de novo protein design methods rely on physics-based force fields to search for low free-energy states following Anfinsen’s thermodynamic hypothesis. A major obstacle of such approaches...

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Detalhes bibliográficos
Main Authors: Mitra, Pralay, Shultis, David, Zhang, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3692067/
https://ncbi.nlm.nih.gov/pubmed/23671331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt384
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