An Evolution-Based Approach to De Novo Protein Design and Case Study on Mycobacterium tuberculosis

Computational protein design is a reverse procedure of protein folding and structure prediction, where constructing structures from evolutionarily related proteins has been demonstrated to be the most reliable method for protein 3-dimensional structure prediction. Following this spirit, we developed...

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Autors principals: Mitra, Pralay, Shultis, David, Brender, Jeffrey R., Czajka, Jeff, Marsh, David, Gray, Felicia, Cierpicki, Tomasz, Zhang, Yang
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812052/
https://ncbi.nlm.nih.gov/pubmed/24204234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003298
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