CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle

Telomere end-protection by the shelterin complex prevents DNA damage signalling and promiscuous repair at chromosome ends. Evidence suggests that the 3’ single-stranded telomere end can assemble into a lasso-like t-loop configuration(1,2), which has been proposed to safeguard chromosome ends from be...

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Veröffentlicht in:Nature
Hauptverfasser: Sarek, Grzegorz, Kotsantis, Panagiotis, Ruis, Phil, Van Ly, David, Margalef, Pol, Borel, Valerie, Zheng, Xiao-Feng, Flynn, Helen R., Snijders, Ambrosius P., Chowdhury, Dipanjan, Cesare, Anthony J., Boulton, Simon J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874499/
https://ncbi.nlm.nih.gov/pubmed/31723267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1744-8
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