Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition

Methylation of the small ribosome subunit rRNA in the ribosomal decoding center results in exceptionally high-level aminoglycoside resistance in bacteria. Enzymes that methylate 16S rRNA on N7 of nucleotide G1405 (m(7)G1405) have been identified in both aminoglycoside-producing and clinically drug-r...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Nosrati, Meisam, Dey, Debayan, Mehrani, Atousa, Strassler, Sarah E., Zelinskaya, Natalia, Hoffer, Eric D., Stagg, Scott M., Dunham, Christine M., Conn, Graeme L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
RNA
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6873201/
https://ncbi.nlm.nih.gov/pubmed/31594862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011181
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