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Heterologous Expression and Functional Characterization of the Exogenously Acquired Aminoglycoside Resistance Methyltransferases RmtD, RmtD2, and RmtG

The exogenously acquired 16S rRNA methyltransferases RmtD, RmtD2, and RmtG were cloned and heterologously expressed in Escherichia coli, and the recombinant proteins were purified to near homogeneity. Each methyltransferase conferred an aminoglycoside resistance profile consistent with m(7)G1405 mod...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Corrêa, Laís L., Witek, Marta A., Zelinskaya, Natalia, Picão, Renata C., Conn, Graeme L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704232/
https://ncbi.nlm.nih.gov/pubmed/26552988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02482-15
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