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Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA
Aminoglycosides are potent, broad spectrum, ribosome-targeting antibacterials whose clinical efficacy is seriously threatened by multiple resistance mechanisms. Here, we report the structural basis for 30S recognition by the novel plasmid-mediated aminoglycoside-resistance rRNA methyltransferase A (...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4035980/ https://ncbi.nlm.nih.gov/pubmed/24717845 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402789111 |
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