Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT–NAD(+)–SIRT1 pathway

Pyruvate is a glycolytic metabolite used for energy production and macromolecule biosynthesis. However, little is known about its functions in tumorigenesis. Here, we report that exogenous pyruvate inhibits the proliferation of different types of cancer cells. This inhibitory effect of pyruvate on c...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Ma, Rui, Wu, Yinsheng, Zhai, Yansheng, Hu, Bicheng, Ma, Wei, Yang, Wenqiang, Yu, Qi, Chen, Zhen, Workman, Jerry L, Yu, Xilan, Li, Shanshan
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868375/
https://ncbi.nlm.nih.gov/pubmed/31598701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz864
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