Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT–NAD(+)–SIRT1 pathway

Pyruvate is a glycolytic metabolite used for energy production and macromolecule biosynthesis. However, little is known about its functions in tumorigenesis. Here, we report that exogenous pyruvate inhibits the proliferation of different types of cancer cells. This inhibitory effect of pyruvate on c...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Ma, Rui, Wu, Yinsheng, Zhai, Yansheng, Hu, Bicheng, Ma, Wei, Yang, Wenqiang, Yu, Qi, Chen, Zhen, Workman, Jerry L, Yu, Xilan, Li, Shanshan
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Gene regulation, Chromatin and Epigenetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868375/
https://ncbi.nlm.nih.gov/pubmed/31598701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz864
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