Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT–NAD(+)–SIRT1 pathway

Pyruvate is a glycolytic metabolite used for energy production and macromolecule biosynthesis. However, little is known about its functions in tumorigenesis. Here, we report that exogenous pyruvate inhibits the proliferation of different types of cancer cells. This inhibitory effect of pyruvate on c...

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Библиографические подробности
Опубликовано в: :Nucleic Acids Res
Главные авторы: Ma, Rui, Wu, Yinsheng, Zhai, Yansheng, Hu, Bicheng, Ma, Wei, Yang, Wenqiang, Yu, Qi, Chen, Zhen, Workman, Jerry L, Yu, Xilan, Li, Shanshan
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2019
Предметы:
Gene regulation, Chromatin and Epigenetics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868375/
https://ncbi.nlm.nih.gov/pubmed/31598701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz864
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