Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT–NAD(+)–SIRT1 pathway

Pyruvate is a glycolytic metabolite used for energy production and macromolecule biosynthesis. However, little is known about its functions in tumorigenesis. Here, we report that exogenous pyruvate inhibits the proliferation of different types of cancer cells. This inhibitory effect of pyruvate on c...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nucleic Acids Res
Päätekijät: Ma, Rui, Wu, Yinsheng, Zhai, Yansheng, Hu, Bicheng, Ma, Wei, Yang, Wenqiang, Yu, Qi, Chen, Zhen, Workman, Jerry L, Yu, Xilan, Li, Shanshan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2019
Aiheet:
Gene regulation, Chromatin and Epigenetics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868375/
https://ncbi.nlm.nih.gov/pubmed/31598701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz864
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