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The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and aging

Aging is associated with a variety of pathophysiological changes, including development of insulin resistance, progressive decline in β-cell function, and chronic inflammation, all of which affect metabolic homeostasis in response to nutritional and environmental stimuli. SIRT1, the mammalian nicoti...

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Detalhes bibliográficos
Main Authors: Imai, Shin-ichiro, Yoshino, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819727/
https://ncbi.nlm.nih.gov/pubmed/24003918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/dom.12171
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