SIRT1-mediated eNAMPT secretion from adipose tissue regulates hypothalamic NAD(+) and function in mice

Nicotinamide phosphoribosyltransferase (NAMPT), the key NAD(+) biosynthetic enzyme, has two different forms, intra- and extracellular (iNAMPT and eNAMPT), in mammals. However, the significance of eNAMPT secretion remains unclear. Here we demonstrate that deacetylation of iNAMPT by the mammalian NAD(...

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Publicado en:Cell Metab
Main Authors: Yoon, Myeong Jin, Yoshida, Mitsukuni, Johnson, Sean, Takikawa, Akiko, Usui, Isao, Tobe, Kazuyuki, Nakagawa, Takashi, Yoshino, Jun, Imai, Shin-ichiro
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426056/
https://ncbi.nlm.nih.gov/pubmed/25921090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.04.002
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