SIRT1-mediated eNAMPT secretion from adipose tissue regulates hypothalamic NAD(+) and function in mice

Nicotinamide phosphoribosyltransferase (NAMPT), the key NAD(+) biosynthetic enzyme, has two different forms, intra- and extracellular (iNAMPT and eNAMPT), in mammals. However, the significance of eNAMPT secretion remains unclear. Here we demonstrate that deacetylation of iNAMPT by the mammalian NAD(...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Yoon, Myeong Jin, Yoshida, Mitsukuni, Johnson, Sean, Takikawa, Akiko, Usui, Isao, Tobe, Kazuyuki, Nakagawa, Takashi, Yoshino, Jun, Imai, Shin-ichiro
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426056/
https://ncbi.nlm.nih.gov/pubmed/25921090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.04.002
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados