Transgenic Archaerhodopsin-3 Expression in Hypocretin/Orexin Neurons Engenders Cellular Dysfunction and Features of Type 2 Narcolepsy

Narcolepsy, characterized by excessive daytime sleepiness, is associated with dysfunction of the hypothalamic hypocretin/orexin (Hcrt) system, either due to extensive loss of Hcrt cells (Type 1, NT1) or hypothesized Hcrt signaling impairment (Type 2, NT2). Accordingly, efforts to recapitulate narcol...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Neurosci
Autori principali: Williams, Rhîannan H., Tsunematsu, Tomomi, Thomas, Alexia M., Bogyo, Kelsie, Yamanaka, Akihiro, Kilduff, Thomas S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2019
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6867809/
https://ncbi.nlm.nih.gov/pubmed/31628177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0311-19.2019
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi