Transgenic Archaerhodopsin-3 Expression in Hypocretin/Orexin Neurons Engenders Cellular Dysfunction and Features of Type 2 Narcolepsy

Narcolepsy, characterized by excessive daytime sleepiness, is associated with dysfunction of the hypothalamic hypocretin/orexin (Hcrt) system, either due to extensive loss of Hcrt cells (Type 1, NT1) or hypothesized Hcrt signaling impairment (Type 2, NT2). Accordingly, efforts to recapitulate narcol...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Williams, Rhîannan H., Tsunematsu, Tomomi, Thomas, Alexia M., Bogyo, Kelsie, Yamanaka, Akihiro, Kilduff, Thomas S.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6867809/
https://ncbi.nlm.nih.gov/pubmed/31628177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0311-19.2019
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