Conditional Ablation of Orexin/Hypocretin Neurons: A New Mouse Model for the Study of Narcolepsy and Orexin System Function

The sleep disorder narcolepsy results from loss of hypothalamic orexin/hypocretin neurons. Although narcolepsy onset is usually postpubertal, current mouse models involve loss of either orexin peptides or orexin neurons from birth. To create a model of orexin/hypocretin deficiency with closer fideli...

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Detalhes bibliográficos
Main Authors: Tabuchi, Sawako, Tsunematsu, Tomomi, Black, Sarah W., Tominaga, Makoto, Maruyama, Megumi, Takagi, Kazuyo, Minokoshi, Yasuhiko, Sakurai, Takeshi, Kilduff, Thomas S., Yamanaka, Akihiro
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012309/
https://ncbi.nlm.nih.gov/pubmed/24806676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0073-14.2014
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