Acute Optogenetic Silencing of Orexin/Hypocretin Neurons Induces Slow-Wave Sleep in Mice

Orexin/hypocretin neurons have a crucial role in the regulation of sleep and wakefulness. To help determine how these neurons promote wakefulness, we generated transgenic mice in which orexin neurons expressed halorhodopsin (orexin/Halo mice), an orange light-activated neuronal silencer. Slice patch...

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Main Authors: Tsunematsu, Tomomi, Kilduff, Thomas S., Boyden, Edward S., Takahashi, Satoru, Tominaga, Makoto, Yamanaka, Akihiro
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2011
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3864636/
https://ncbi.nlm.nih.gov/pubmed/21775598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0784-11.2011
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