Influence of Inhibitory Serotonergic Inputs to Orexin/Hypocretin Neurons on the Diurnal Rhythm of Sleep and Wakefulness

STUDY OBJECTIVE: Serotonergic (5HT) neurons of the dorsal raphe nuclei receive excitatory input from hypothalamic orexin (hypocretin) neurons and reciprocally inhibit orexin neurons through the 5HT1A receptor. However, the physiological significance of this negative feedback circuit for sleep/wakefu...

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Detalhes bibliográficos
Main Authors: Tabuchi, Sawako, Tsunematsu, Tomomi, Kilduff, Thomas S., Sugio, Shouta, Xu, Ming, Tanaka, Kenji F., Takahashi, Satoru, Tominaga, Makoto, Yamanaka, Akihiro
Formato: Artigo
Idioma:Inglês
Publicado em: Associated Professional Sleep Societies, LLC 2013
Assuntos:
Influence of Serotonergic Inputs to Orexin/Hypocretin Neurons
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738049/
https://ncbi.nlm.nih.gov/pubmed/23997373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5665/sleep.2972
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