The Fundamental Role of Chromatin Loop Extrusion in Physiological V(D)J Recombination

RAG endonuclease initiates IgH locus (Igh) V(D)J assembly in progenitor (pro)-B cells by joining Ds to J(H)s, before joining upstream V(H)s to DJ(H) intermediates(1). In mouse pro-B cells, the CTCF-binding element (CBE)-anchored chromatin loop domain(2) at the 3’end of Igh contains an internal sub-d...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Zhang, Yu, Zhang, Xuefei, Ba, Zhaoqing, Liang, Zhuoyi, Dring, Eddie, Hu, Hongli, Lou, Jiangman, Kyritsis, Nia, Zurita, Jeffrey, Shamim, Muhammad S., Aiden, Aviva Presser, Aiden, Erez Lieberman, Alt, Frederick W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6867615/
https://ncbi.nlm.nih.gov/pubmed/31511698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1547-y
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