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CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning
RAG endonuclease initiates V(D)J recombination in progenitor (pro)-B cells(1). Upon binding a recombination center (RC)-based J(H), RAG scans upstream chromatin via loop extrusion, potentially mediated by cohesin, to locate Ds and assemble a DJ(H)-based RC(2). CTCF looping factor-bound elements (CBE...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7554077/ https://ncbi.nlm.nih.gov/pubmed/32717742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2578-0 |
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