Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability

Although correlations between RNA polymerase II (RNAPII) transcription stress, R-loops, and genome instability have been established, the mechanisms underlying these connections remain poorly understood. Here, we used a mutant version of the transcription elongation factor TFIIS (TFIIS(mut)), aiming...

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Udgivet i:Mol Cell
Main Authors: Zatreanu, Diana, Han, Zhong, Mitter, Richard, Tumini, Emanuela, Williams, Hannah, Gregersen, Lea, Dirac-Svejstrup, A. Barbara, Roma, Stefania, Stewart, Aengus, Aguilera, Andres, Svejstrup, Jesper Q.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863433/
https://ncbi.nlm.nih.gov/pubmed/31519522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.07.037
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