N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis

Pancreatic ductal adenocarcinoma is one of the most invasive and metastatic cancers and has a dismal 5-year survival rate. We show that N-WASP drives pancreatic cancer metastasis, with roles in both chemotaxis and matrix remodeling. lysophosphatidic acid, a signaling lipid abundant in blood and asci...

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Publicat a:Dev Cell
Autors principals: Juin, Amelie, Spence, Heather J., Martin, Kirsty J., McGhee, Ewan, Neilson, Matthew, Cutiongco, Marie F.A., Gadegaard, Nikolaj, Mackay, Gillian, Fort, Loic, Lilla, Sergio, Kalna, Gabriela, Thomason, Peter, Koh, Yvette W.H., Norman, Jim C., Insall, Robert H., Machesky, Laura M.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863394/
https://ncbi.nlm.nih.gov/pubmed/31668663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.09.018
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